Alien Syndrome NES box art

Nintendo Entertainment System · Action / Shooter

Alien Syndrome

Deep cut Co-op

SystemNintendo Entertainment System
Released1988 (originally 1987)
GenreAction, Shooter
DeveloperSEGA
PublisherTengen
Players1–2 players (co-op)
CommitmentAn evening or two (Roughly 1–6 hours to see it through)
SeriesAlien Syndrome
ESRBE
LegacyDeep cut · legacy score 4

Alien Syndrome is an action game released in 1988 for the Nintendo Entertainment System, developed by SEGA and published by Tengen. This NES release is a port or adaptation of a game that first appeared in 1987. It blends action and shooter elements.

It landed about 3 years into the NES's life. Other notable NES releases from 1988 include Super Mario Bros. 3, Super Mario Bros. 2 and Final Fantasy II.

It is part of the Alien Syndrome series. The series also appears on other systems with Alien Syndrome (Master System) and Alien Syndrome (C64).

Alien Syndrome supports up to 2 players, including cooperative play, which makes it a strong pick for playing with a friend.

Pick it if…

  • you want to fight, blast and test your reflexes
  • you have time for an evening or two (roughly 1–6 hours to see it through)
  • you want a game to beat together with a friend
  • you've played the NES hits and want something less obvious

Maybe skip it if…

  • you prefer slow, thoughtful games over reflex tests

What playing Alien Syndrome is like

Action games test reflexes and nerve. Expect fast enemies, tight controls and stages you clear by reacting quickly and learning enemy patterns.

Tip for newcomers: Retro action games are often short but tough. Treat early deaths as practice runs; every attempt teaches you where the next threat comes from.

Alien Syndrome gameplay screenshot on NES
In-game screenshot (NES)

Alien Syndrome cheats & codes

21 codes on file (Game Genie, Other codes). Here are a few Game Genie codes to start with:

Infinite TimeSZUNYXVK
Set Timer To 440GUONPPLL
Both Players (1 Life)PAOGPIGA
Both Players (8 Lives)AAOGPIGE
Start With Flame ThrowerPAVKGIAA
Start With FireballZAVKGIAA

See all Alien Syndrome cheats

Alien Syndrome walkthroughs & guides

Stuck, or want to go deeper? These trusted sites have full walkthroughs, completion times and more for Alien Syndrome.

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Playing NES games today

NES games are short on paper but often famously tough, so expect to replay levels and learn patterns. Many first-party titles are available through Nintendo Switch Online, original cartridges remain easy to find, and you can play backups of games you own in an emulator such as Rec0m88.

Alien Syndrome FAQ

When did Alien Syndrome come out on the NES?

Alien Syndrome was released for the Nintendo Entertainment System in 1988; the original game dates back to 1987.

Who made Alien Syndrome?

It was developed by SEGA and published by Tengen.

Is Alien Syndrome multiplayer?

Yes. Alien Syndrome supports up to 2 players, including co-op play.

How long does Alien Syndrome take to play?

As an action game, Alien Syndrome typically falls into the "An evening or two" category: roughly 1–6 hours to see it through. Your time will vary with skill and how much you explore.

Read more about Alien Syndrome on Wikipedia. Facts on this page are compiled from the open libretro database and Wikidata; "legacy score" reflects how widely a game is documented across Wikipedia's language editions. Spotted an error? Let us know.

Not sure? Let the Matrix pick for you